When an eccentric millionaire offer a group of opposites $1,000,000 to spend the night in a so called "Haunted House" with a murderous past, they figure it is a quick way to get quick money and leave. All of them are sure it is some made up story just to mess with their heads a little and test their courage. But, once they stay in the house they start to think about the mistake they made in coming there when mysterious things start to happen.

Three odd-ball scientists get kicked out of their cushy positions at a university in New York City where they studied the occult. They decide to set up shop in an old firehouse and become Ghostbusters, trapping pesky ghosts, spirits, haunts, and poltergeists for money. They wise-crack their way through the city, and stumble upon a gateway to another dimension, one which will release untold evil upon the city. The Ghostbusters are called on to save the Big Apple.